0.CO;2-J.” href=”/articles/-2350-8-18#ref-CR6″ >6, 21], POF problems should be thought about given that multifactorial problems and also in see with the, studying the phenotypical and you may hereditary popular features of the fresh new times you are going to contribute into the dropping of the latest white into high difficulty out-of POF.
To summarize, all of our instance statement is short for an original observation into coexistence within this you to definitely family of different facets involved in a couple of more ovarian incapacity criteria, one-FMR1 associated and one perhaps not-FMR1 related. On top of that, it may be noticed a significant warning on hereditary counselling away from familial POF. Particularly, we believe that connection of POF that have expanded FMR1 alleles must be verified through the generations enabling the newest medical counselling of familial POF and in the end new utilization of techniques to get better conception.
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