Lyrica Uses, How to Take, Side Effects, Warnings

Lyrica is used to treat pain caused by fibromyalgia, or nerve pain in people with diabetes (diabetic neuropathy), herpes zoster (post-herpetic neuralgia), or spinal cord injury. Drowsiness, dizziness, dry mouth, constipation, difficulty concentrating, or weight gain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

This article does not contain all drugs that may interact with Lyrica. If you’re interested in stopping your Lyrica treatment, talk with your doctor first. Lyrica can also cause respiratory depression if taken with other drugs that depress the central nervous system (CNS), such as opioids. However, people with diabetes should pay special attention to their skin while taking Lyrica. Anyone with a history of misusing drugs or alcohol may be more likely to misuse Lyrica. If you have questions or concerns about misusing Lyrica, talk with your doctor before you start treatment.

CLINICAL PHARMACOLOGY

In comparison, less than 1% of patients in the placebo group withdrew due to each of these events. In this study, LYRICA 2.5 mg/kg/day (maximum 150 mg/day) and 10 mg/kg/day (maximum 600 mg/day) were compared to placebo. Administration of each daily dose was divided into two equal doses (twice a day dosing). The mean duration of epilepsy was 6 years and the mean and median baseline seizure frequencies were 57 and 18 seizures per month, respectively. Approximately 74% of the patients were taking 2 to 3 concurrent AEDs at baseline. Among the LYRICA-treated patients, 87% completed the double-blind phase of the study.

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The actual price you’ll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. Here’s a list of conditions that the Food and Drug Administration (FDA) has approved Lyrica and gabapentin to treat. To help make sure you don’t miss a dose, try using a medication reminder. Regardless of the condition that Lyrica is being used to treat, its manufacturer recommends adjusting the dosage for people with kidney problems. If you have kidney problems, talk with your doctor for more details.

NERVIGESIC 300- Pregabalin 300 Mg Capsule

This information can be helpful for doctors and people considering using these drugs during pregnancy. Before approving coverage for Lyrica, your insurance company may require you can you buy lyrica without a prescription to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug.

• They’ll likely monitor you for any symptoms of respiratory depression during your treatment, or they may have you try a different medication for your condition.
• In premarketing controlled trials of all adult populations combined, 14% of patients treated with LYRICA and 7% of patients treated with placebo discontinued prematurely due to adverse reactions.
• If you’re interested in this option, check with your doctor or your insurance company.
• This medicine may increase your or your child’s risk for cancer (eg, hemangiosarcoma) and bleeding.
• LYRICA is contraindicated in patients with known hypersensitivity to pregabalin or any of its components.

This availability linked with relatively low price products and availability of pharmacies is speculated to lead to abuse of a wide variety of OTC and prescription drugs (Albsoul-Younes et al., 2010). A recent concerning trend was the abuse of the anticonvulsant drug (pregabalin), which obtained from pharmacies without a prescription and was not been mentioned previously in Jordan (Wazaify et al., 2017a). The risks of addiction to prescription drugs rise when they are used in means other than prescribed (e.g. at higher doses, by other routes of administration, or mixed with alcohol or other drugs) (NIDA, 2014).

Table 7 lists all dose-related adverse reactions occurring in at least 2% of all LYRICA-treated patients. Dose-relatedness was defined as an incidence of the adverse event in the 10 mg/kg/day group that was at least 2% greater than the rate in both the placebo and 2.5 mg/kg/day groups. In this study, 201 patients received LYRICA and 94 patients received placebo for up to 12 weeks. A majority of pregabalin-treated patients in the clinical study had adverse reactions with a maximum intensity of “mild” or “moderate”. The recommended dose of LYRICA for fibromyalgia is 300 to 450 mg/day.

If you have unused medication that has gone past the expiration date, ask your pharmacist if you can still use it. Lyrica is also available as a liquid solution that you take by mouth. If you have trouble swallowing Lyrica capsules, talk with your doctor or pharmacist. Or, your doctor may have you try a different treatment for your condition. If you have questions about using Lyrica with other medications, talk with your doctor or pharmacist. If you’re using Lyrica to treat a condition other than seizures, your doctor may have you take other medications with Lyrica, or they may have you use Lyrica on its own.

Pregabalin was detected in breast milk at average steady-state concentrations approximately 76% of those in maternal plasma. The estimated average daily infant dose of pregabalin from breast milk (assuming mean milk consumption of 150 mL/kg/day) was 0.31 mg/kg/day, which on a mg/kg basis would be approximately 7% of the maternal dose. The study did not evaluate the effects of LYRICA on milk production. Infants did not receive breast milk obtained during the dosing period, therefore, the effects of LYRICA on the breast fed infant were not evaluated. Table 8 lists all dose-related adverse reactions occurring in at least 2% of all LYRICA-treated patients. Dose-relatedness was defined as an incidence of the adverse event in the 14 mg/kg/day group that was at least 2% greater than the rate in both the placebo and 7 mg/kg/day groups.

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The recommended dose of LYRICA is 75 to 150 mg two times a day, or 50 to 100 mg three times a day (150 to 300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Begin dosing at 75 mg two times a day, or 50 mg three times a day (150 mg/day). Possible side effects of Lyrica include loss of balance or coordination, problems with memory or concentration, tremors, weight gain, and vision problems. Remember that higher doses usually coincide with more side effects.