Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physical purpose and you may pharmacology from curcumin
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin is the major component of brand new yellow dye off turmeric, an enthusiastic Indian spruce that’s taken from the rhizome of one’s exotic bush Curcuma longa, and that belongs to the Zingiberaceae family relations. Within this part, we talk about the pharmacological circumstances out-of curcumin and speak about the brand new unit angles for those activities. We upcoming feedback the new confirmed and you can prospective logical uses from curcumin. Curcumin is famous over the years since the a curative broker, but its system of step is actually intricate. The fresh new pharmacological results of curcumin seem to be caused by a good synergism out of sites regarding weakened biochemical relations which have multiple physical goals during the interrelated signaling routes. Such purpose tend to be nutrients such as for instance cyclooxygenase, lipoxygenase and you will proteins kinases, and you may transcription situations such as NF-?B, STAT and you may Nrf2. Modulation of those molecules influences downstream affectors that produce new Italiensk kvindelige personals antiinflammatory, antioxidant, chemopreventive, anticancer, and you will antimicrobial products out-of curcumin. This type of consequences was in fact checked in the medical samples regarding curcumin to have aches and you may inflammatory sickness, disease, Alzheimer situation, cardio ailment, and diabetes. This new trials used adjustable dosage out of curcuminwith different wavelengths and you may duration, toward general conclusion one highest dosages out-of curcumin on quantity of grams have to see healing effects. Read more
Curcumin: Synthesis, Growing Character inside the Pain Government and you will Health Effects
Guide Section Types of bush-derived pharmaceuticals that have end up being the appeal of continued and you may rapid search and you may advancement attract enjoys, thus far, become somewhat scarce. Shortly after several years, the very last 20 years was in fact characterized by a 100-fold boost in the amount of medical content wrote per year one is actually from value on the accessibility curcumin inside biomedicine. Read more
Construction, synthesis and you will biological products away from curcumin prodrugs
Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has many prospective pharmacological effects and may even have therapeutic apps in several disease says, due to the fact chatted about in more detail in the previous section. But not, the possibility clinical efficacy from curcumin is bound from the the physicochemical attributes from poor liquids solubility and you will imbalance, and that produce reasonable bioavailability. Prodrugs away from curcumin promote an approach to update of your biopharmaceutical and you will pharmacokinetic services, and may allow it to be exploitation of your own pharmacological results of curcumin. Within this chapter, i first remark brand new physicochemical and you may pharmacokinetics out of curcumin. I up coming describe the appearance of curcumin prodrugs that have improved liquids solubility and you may enhanced agents balances which are converted back into 100 % free curcumin through to bioactivation within the vivo. I focus on recent achievements in this area, having a concentrate on the build, synthesis and you can investigations away from prodrugs based on promoieties in addition to proteins, essential fatty acids, nucleic acids, dicarboxylic acids, and you may polymeric material such as for instance hyaluronic acidic and you may polyethylene glycol. That it part provides the reason for optimization of the physicochemical and you will biopharmaceutical characteristics while the physical things off curcumin prodrugs, towards purpose playing with of these curcumin derivatives into the scientific programs. Find out more
